DAB (Dimethyl-amino-azobenzol)肝癌発生に及ぼす乾燥脳下垂体及び乾燥副腎皮質の影響

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  • The effcet of inplanted dried tissues of pituitary & adrenal glands on the tumor induction by DAB

説明

In recent years there has been a great deal of interest in the relationship of adrenocortical and pituitary hormons and their influence on the development of malignant tumors. During the past 3 years I have been studing the effect of dried tissues of adrenal and pituitary glands, implanted into subcutaneous tisuse on the tumor induction in the rats fed with dimethyl-amino-azobenzol (DAB)<br>The animal used were inbred ones cultured in our institute from a pair of hybrid rats which showed a high susceptibility for DAB. The liver tumors appeared after about 120 days feeding of DAB. Malignant adenocarcinoma was predominant in the beginning and then typical hepatoma appeared. Continued feeding with DAB resulted in the rapid growth of tumors and the development to the more malignant types of hepatocellular or cholangiocellular carcinoma.<br>Pituitary tissue effected an aceelerated tumor induction and the earlier development of the malignant type, Adrenal tissue showed a slight inhibitory effect on tumor growth. Simultaneous inplantation of pituitary and adrenal tissue represented a marked inhibitory effect on the tumor induction by DAB.

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