Lymphoid infiltration of the primary tumor in gastric cancer

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  • 胃癌予後因子としての胃癌巣周囲のリンパ球浸潤
  • イガン ヨゴ インシ トシテノ イガン スシュウイ ノ リンパキュウ シンジュ

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The correlation among lymphoid infiltration (LI) in the primary tumor, cell-mediated immunity and the accumulative 5-year survival rate was studied in 515 patients with resected gastric cancer. As scales of cell-mediated immunity, the blastformation rate of peripheral lymphocytes against phytohemagglutinin (PHA) -M (Difco) and the PPD skin reaction were examined. The results were as follows:<br>1) LI of the primary tumor was found in 124 out of 515 patients (24.1%); patients with marked LI were 6.4%.<br>2) The blastformation rate in patients with positive LI was significantly higher than that in patients with negative LI (p<0.01).<br>3) The LI of the primary tumor tended to be found commonly in patients with gastric cancer in clinical stage I.<br>4) The blastformation rate decreased when the clinical stage of gastric cancer progressed, however, this trend was not seen in patients with positive LI regardless of the stage.<br>5) The accumulative 5-year survival rate in patients with positive LI was longer than that in the patients with LI negative (p<0.05).<br>6) There was no relationship among the degrees of LI in the primary tumor, the PPD skin reaction and lymphocyte count.<br>In conclusion, LI of the primary tumor has a close relationship with the blastformation rate, and this phenomenon suggests that a local appearance of cell-mediated immunity in the cancer bearing body may occur.

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