ストレス潰瘍の発生と生体リズム(ストレスの基礎と臨床)(第27回日本心身医学会総会)

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  • Chronobiological Approach on the Etiology of Activity-stress Ulcer in Rats(Stress-Its fundamentals and ckinical aspects)
  • ストレス潰瘍の発生と生体リズム
  • ストレス カイヨウ ノ ハッセイ ト セイタイ リズム

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When the rat was housed individually in an activity-wheel cage on restricted feeding schedule, the running activity increased progressively and some rats died following a sudden decrease of running activity. The majority of rats manifested severe gastric mucosal lesions only inYthe glandular portion of the stomach. Par & Houser (1973) gave these lesions the designation of "activity-stress ulcer". Among the variables affecting the development of activitystress (AS) ulcer the augmentation of running activity on a restricted feeding schedule has been considered to be most important. To my knowledge, however, there has been no other study in which the relation between rhythmicity of running activity and gastric ulceration was clearly demonstrated. We conducted several series of experiments to investigate the etiology of AS ulcer from the chronobiological standpoint. All animals employed were Long-Evans rats. The light-dark cycle in the vivarium was kept constant (light on at 7 : 00 and off at 19 : 00). An activity-wheel cage consisted of a runningwheel and wiremesh cage allowing access to food and water. Revolutions of each running wheel were recorded automatically at intervals of 30 min by an electrical counting system. To pursue a time-dependent change in the gastric mucosal surface, endoscopic observation was applied using an ultra-thin fiberscope. Although rats showed a typical nocturnal running activity during the unrestricted feeding period for habituation, a remarkable deterioration in circadian rhythmicity of running activity was found as a function of the day of restricted feeding ; the ratio of ligh-ttime revolutions to total revolutions per day increased progressively. Periodical endoscopic observations indicated that the deterioration in circadian rhythmicity closely correlated with the course of gastric ulceration. In this symposium, I presented effects of experimental manipulations, which can modify the development of AS ulcer, on circadian rhythmicity of running activity, and discussed the significance of chronobiological approach on the ethiology of AS ulcer in rats.

収録刊行物

  • 心身医学

    心身医学 27 (1), 53-60, 1987

    一般社団法人 日本心身医学会

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