Altered Energy Metabolism in Anti-aging and Pro-longevity Effects of Caloric Restriction(New Horizon of Eating Disorders)

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  • Higami Yoshikazu
    Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science

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  • 脂質代謝の変化からみたカロリー制限による抗老化・寿命延長作用のメカニズム(摂食障害の新たな展開,2011年,第52回日本心身医学会総会ならびに学術講演会(横浜))
  • 脂質代謝の変化からみたカロリー制限による抗老化･寿命延長作用のメカニズム
  • シシツ タイシャ ノ ヘンカ カラ ミタ カロリー セイゲン ニ ヨル コウロウカ ・ ジュミョウ エンチョウ サヨウ ノ メカニズム

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Abstract

Caloric restriction (CR) has been applied as a powerful tool in aging research. CR is accepted as a robust, reproducible and simple experimental manipulation known to extend both median and maximum lifespans, and to retard and suppress a broad spectrum of pathophysiological changes in a variety of mammals. In general, CR delays skeletal and sexual maturation, reduces body size with less adiposity, lowers body temperature, modulates hyperglycemia and insulinemia, alters lipid and energy metabolisms, protects against internal oxidative and environmental stresses, and activates mitochondrial biogenesis and sirtuins. Based on the adaptive response hypothesis against food shortage, I propose that CR promotes adipose tissue remodeling and modulates energy metabolism via sterol regulatory element binding protein (SREBP) 1c, a master transcriptional factor of fatty acid biosynthesis. Activation of de novo fatty acid biosynthesis regulated by SREBP1c might play an important role in the anti-aging and lifespan extension by caloric restriction.

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