A Role of Ghrelin as a Psycho-somatic Peptide

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  • Asakawa Akihiro
    Division of Diabetes, Digestive and kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine
  • Inui Akio
    Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences

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  • Ghrelinの心身相関ペプチドとしての役割
  • Ghrelin ノ シンシン ソウカン ペプチド ト シテ ノ ヤクワリ

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Abstract

Ghrelin, an endogenous ligand for growth-hormone secretagogue receptor (GHS-R), was recently identified in the stomach with structural resemblance to motilin. Ghrelin induces a state of positive energy balance and body weight gain by promoting food intake, decreasing energy expenditure and stimulating GH secretion. The expression and secretion are increased by fasting and are decreased by feeding. In addition, diet-induced weight loss increases plasma ghrelin level in humans. Moreover, ghrelin influences anxiety, memory retention, cardiac performance, gut motility, glucose metabolism and adipose tissue. These observations suggest that gastric peptide ghrelin and the receptors may be potential therapeutic targets for various diseases.

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