Animal Research of Eating Disorders based on the Clinical Aspects(Symposium/The Forefront of Eating Disorder Research)

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  • 摂食障害の臨床知見を考慮した動物モデル研究(シンポジウム:摂食障害研究の最前線,2008年,第49回日本心身医学会総会(札幌))
  • 摂食障害の臨床知見を考慮した動物モデル研究
  • セッショク ショウガイ ノ リンショウ チケン オ コウリョシタ ドウブツ モデル ケンキュウ

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Abstract

The patients of eating disorders like anorexia nervosa or bulimia nervosa are increasing in number especially among young female. However, the pathology of eating disorders has not been clarified because so many factors as socio-cultural factors, psychological factors, and biological factors are indicated to be concerned. In addition, the methods of treatment have not been established yet. To investigate the biological brain mechanisms of eating disorders, many types of animal models have been proposed. According to the clinical feature of the patients, anorexic status in adolescent female rats was set by food restriction. Psychological and physiological stress changed the feeding behavior in the anorexic status, and the relations of the behavioral changes and the brain neurotransmitters were examined. Those results suggested that abnormalities in many brain neurotransmitters are concerned in anorexic behavior, binge-eating behavior, and anxiety. We can speculate some part of biological bases of human eating disorders, and effective prevention and treatment through such animal models.

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