Roles of Inflammation in Stress-induced Emotional Changes

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  • ストレスによる情動変容の誘導における炎症の役割
  • ストレス ニ ヨル ジョウドウ ヘンヨウ ノ ユウドウ ニ オケル エンショウ ノ ヤクワリ

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<p>Social and environmental stress evokes stress responses through endocrine, immune and autonomic nervous systems. However, how these stress responses are integrated to promote emotional changes and mental illnesses remains poorly understood. Recent studies have established critical roles of inflammation-like responses in stress-induced emotional changes, and have been studying about the involvement of endocrine, immune and autonomic nervous systems. In the periphery, stress-induced endocrine responses activate myeloid cells and increase proinflammatory cytokines, whereas stress-induced sympathetic activation increases the numbers of neutrophils and monocytes in the blood. Stress also alters the composition of gut microbiota and activates immune systems. In the brain, stress activates microglial cells and suppresses dopaminergic system in the prefrontal cortex through inflammation-related molecules. These findings suggest that multiple stress responses are converged to inflammation-like responses inside and outside the brain, thereby promoting emotional changes and mental illnesses, and have led us to propose that stress-induced inflammation-like responses are a target for therapeutic development of novel antidepressants.</p>

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