Evaluation of Streptozyme Test and Antistreptolysin O Tests in the Diagnosis of Secondary Streptococcal Infection (Especially in Poststreptococcal Acute Glomerulonephritis)

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  • 溶連菌感染二次症(とくに溶連菌感染後急性糸球体腎炎)の診断におけるストレプト・ザイムテスト及び ASLO テストの評価
  • ヨウレンキン カンセン ニジショウ トクニ ヨウレンキン カンセンゴ キュウセ

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Abstract

Positive serological reaction of preceeding streptococcal infection is one of the most important criterial of clinical diagnosis of poststreptococcal glomerulonephritis. For this purpose, the measurement of ASLO titer has been widely utilized. However, this test is not always positive in all patients with streptococcal infection. Recently, the hemaggultination test to the five different extracellular streptococcal toxins in addition to SLO was developed and is expected to raise the positive incidence of serological diagnosis of streptococcal infection. In order to evaluate the reliance of this test, ASLO and this new test (streptozyme test) were simultaneously measured in the same sample. Samples tested were 264. As the result, the positive incidence of both tests were closely correlated (r=0.828, p<0.01) and samples which were under 125U of ASLO titer showed positive results in streptozyme test. The chronological measurement of ASLO and streptozyme test in two patients with typical PSAGN also showed parallel change in their titers. It is concluded that streptozyme test is useful for the diagnosis of preceeding streptococcal infection in PSAGN.

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