Study on a Quantitative Determination of Occult Blood in Feces by Full-Automated Analyser

  • SAKURAI Michie
    Department of Clinical Laboratories, Kyorin University Hospital
  • SHUKUYA Kenichi
    Department of Clinical Laboratories, Kyorin University Hospital
  • SANO Emi
    Department of Clinical Laboratories, Kyorin University Hospital
  • HARADA Kiyoko
    Department of Clinical Laboratories, Kyorin University Hospital
  • MAEKAWA Hiroyuki
    Department of Clinical Laboratories, Kyorin University Hospital
  • EGAMI Teruo
    Department of Clinical Laboratories, Kyorin University Hospital
  • HURUYA Nobushige
    Department of Clinical Laboratories, Kyorin University Hospital
  • UCHIMURA Hidemasa
    Department of Clinical Laboratories, Kyorin University Hospital

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Other Title
  • 便潜血反応の定量的測定法 : ヒトヘモグロビンの自動測定装置による検討

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We examined the usefulness of the quantitative measurement of occult blood in feces by using full-automated analyser, OC-sensor. Linearity of calibration curve was found up to the concentration of 1000ng/ml. Intra-and inter-assay variation (cv%) were 3.2〜11.3 and 5.4〜13.6, respectively. Three hundred fifty four specimens which occult blood was negative by qualitative test showed 0〜99 ng/ml of Hb concentrations by OC-sensor analyser. Fifty eight specimens which were positive by the qualitative test showed 50〜2000ng/ml of Hb concentrations. When tentative cut off value was defined as 50ng/ml, coincidence rate of negative and positive was 94.1% and 84.5%, respectively. These results indicate that a new quantitative method to determine occult blood in feces by the automated analyser, OC-sensor, is useful for routine test and could be available as screening test for colonic cancer.

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