Administration of anti-glucagon-like peptide-2 serum suppresses epithelial cell proliferation of the distal small intestine in weanling rats
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- Ishizuka Satoshi
- Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University
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- Inafune Ayako
- Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University
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- Hira Tohru
- Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University
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- Izumi Hirohisa
- Nutritional Science Laboratory, Morinaga Milk Industry Co. Ltd.
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- Ozawa Kazuhiro
- Nutritional Science Laboratory, Morinaga Milk Industry Co. Ltd.
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- Takase Mitsunori
- Nutritional Science Laboratory, Morinaga Milk Industry Co. Ltd.
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- Hara Hiroshi
- Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University
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抄録
We investigated the effects of endogenous glucagon-like peptide-2 (GLP-2) on the development of intestinal mucosa in weanling rats. Three-week-old male weanling Sprague-Dawley rats were administered either anti-GLP-2 or normal rabbit serum every other day for 2 weeks. We then measured length, weight, and bromodeoxyuridine incorporation in the intestine on day 13 following the first injection. Administration of anti-GLP-2 serum significantly inhibited both epithelial proliferation in the distal ileum and elongation of the small intestine. These results suggest that intrinsic GLP-2 contributes to the growth of the small intestine during the weanling period.
収録刊行物
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- Biomedical Research
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Biomedical Research 30 (4), 259-261, 2009
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