Administration of anti-glucagon-like peptide-2 serum suppresses epithelial cell proliferation of the distal small intestine in weanling rats

  • Ishizuka Satoshi
    Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University
  • Inafune Ayako
    Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University
  • Hira Tohru
    Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University
  • Izumi Hirohisa
    Nutritional Science Laboratory, Morinaga Milk Industry Co. Ltd.
  • Ozawa Kazuhiro
    Nutritional Science Laboratory, Morinaga Milk Industry Co. Ltd.
  • Takase Mitsunori
    Nutritional Science Laboratory, Morinaga Milk Industry Co. Ltd.
  • Hara Hiroshi
    Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University

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抄録

We investigated the effects of endogenous glucagon-like peptide-2 (GLP-2) on the development of intestinal mucosa in weanling rats. Three-week-old male weanling Sprague-Dawley rats were administered either anti-GLP-2 or normal rabbit serum every other day for 2 weeks. We then measured length, weight, and bromodeoxyuridine incorporation in the intestine on day 13 following the first injection. Administration of anti-GLP-2 serum significantly inhibited both epithelial proliferation in the distal ileum and elongation of the small intestine. These results suggest that intrinsic GLP-2 contributes to the growth of the small intestine during the weanling period.

収録刊行物

  • Biomedical Research

    Biomedical Research 30 (4), 259-261, 2009

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