Cardiac Sympathetic Activity Assessed by Heart Rate Variability Indicates Myocardial Ischemia on Cold Exposure in Diabetes

DOI 16 References
  • Sasaki Keita
    School of Medicine, University of Tsukuba, Tsukuba, Japan
  • Matsushita Shonosuke
    Graduate School of Comprehensive Human Science, Department of Cardiovascular Surgery, University of Tsukuba, Tsukuba, Japan
  • Sato Fujio
    Graduate School of Comprehensive Human Science, Department of Cardiovascular Surgery, University of Tsukuba, Tsukuba, Japan
  • Tokunaga Chiho
    Graduate School of Comprehensive Human Science, Department of Cardiovascular Surgery, University of Tsukuba, Tsukuba, Japan
  • Hyodo Kazuyuki
    High Energy Accelerator Research Organization: KEK, Tsukuba, Japan
  • Sakakibara Yuzuru
    Graduate School of Comprehensive Human Science, Department of Cardiovascular Surgery, University of Tsukuba, Tsukuba, Japan

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  • 心臓交感神経指標を用いた寒冷負荷による糖尿病心筋虚血リスクの評価

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Abstract

Measurement of heart rate variability (HRV) is a non-invasive technique that can be used to investigate functioning of the autonomic nervous system, especially the balance between sympathetic and vagal activities. It is reported that dilatation of coronary microcirculation by augmentation of sympathetic nerve activity (SNA) caused by cold exposure was impaired in diabetes. The question of whether or not SNA in HRV could respond to coronary ischemia was evaluated by cold exposure in diabetic rats. It was found that diabetes with weight loss significantly increased SNA both in baseline and cold exposure, compared with control. A correspondence was also found with coronary ischemia. It can be concluded that measurement of HRV may provide useful information regarding the coronary risk of cold exposure in diabetes.

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