Toxicogenomics/proteomics report: Proteomics analysis of cardiac muscle from rats with peroxisomal proliferator-activated receptorα (PPARα) stimulation
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- Miyazaki Masafumi
- ActivX Biosciences Inc. Discovery Research laboratories, Kyorin Pharmaceutical Co., Ltd.
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- Nakagawa Ippei
- Discovery Research laboratories, Kyorin Pharmaceutical Co., Ltd.
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- Koga Shigeru
- Discovery Research laboratories, Kyorin Pharmaceutical Co., Ltd.
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- Kasahara Yasushi
- Discovery Research laboratories, Kyorin Pharmaceutical Co., Ltd.
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- Patricelli Matthew P.
- ActivX Biosciences Inc.
書誌事項
- タイトル別名
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- Proteomics analysis of cardiac muscle from rats with peroxisomal proliferator-activated receptor .ALPHA. (PPAR.ALPHA.) stimulation
- Toxicogenomics proteomics report Proteomics analysis of cardiac muscle from rats with peroxisomal proliferator activated receptor a PPAR a stimulation
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説明
To investigate peroxisomal proliferator-activated receptor α (PPARα) signal responses in heart muscle, we performed LC-MS/MS-based proteomics analysis of heart muscle from rats given fenofibrate or clofibrate. Fenofibrate increased the expression of ACAA2, DECR1, and ECH1 consistent with activation of PPARα. Fenofibrate and clofibrate reduced the expression of 10 and 12 proteins, respectively with the expression of ACSL1, SLC25A4, A1BG, HADHA, ATP2A2, BDH1, ETFDH, HADHB, and CPT2 being reduced in common with both of fibrate-treated groups. The approach adopted in this study provides an efficient method for monitoring global changes in protein expression.
収録刊行物
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- Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｔｏｘｉｃｏｌｏｇｉｃａｌ Ｓｃｉｅｎｃｅｓ
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Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｔｏｘｉｃｏｌｏｇｉｃａｌ Ｓｃｉｅｎｃｅｓ 35 (1), 131-135, 2010
一般社団法人 日本毒性学会
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詳細情報 詳細情報について
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- CRID
- 1390282679877107968
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- NII論文ID
- 10025983590
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- NII書誌ID
- AN00002808
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- ISSN
- 18803989
- 03881350
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- NDL書誌ID
- 10578874
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDLサーチ
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