Proteomics analysis of cardiac muscle from rats with peroxisomal proliferator-activated receptor .ALPHA. (PPAR.ALPHA.) stimulation
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- Miyazaki Masafumi
- ActivX Biosciences Inc. Discovery Research laboratories, Kyorin Pharmaceutical Co., Ltd.
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- Nakagawa Ippei
- Discovery Research laboratories, Kyorin Pharmaceutical Co., Ltd.
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- Koga Shigeru
- Discovery Research laboratories, Kyorin Pharmaceutical Co., Ltd.
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- Kasahara Yasushi
- Discovery Research laboratories, Kyorin Pharmaceutical Co., Ltd.
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- Patricelli Matthew P.
- ActivX Biosciences Inc.
Bibliographic Information
- Other Title
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- Toxicogenomics/proteomics report: Proteomics analysis of cardiac muscle from rats with peroxisomal proliferator-activated receptorα (PPARα) stimulation
- Toxicogenomics proteomics report Proteomics analysis of cardiac muscle from rats with peroxisomal proliferator activated receptor a PPAR a stimulation
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Abstract
To investigate peroxisomal proliferator-activated receptor α (PPARα) signal responses in heart muscle, we performed LC-MS/MS-based proteomics analysis of heart muscle from rats given fenofibrate or clofibrate. Fenofibrate increased the expression of ACAA2, DECR1, and ECH1 consistent with activation of PPARα. Fenofibrate and clofibrate reduced the expression of 10 and 12 proteins, respectively with the expression of ACSL1, SLC25A4, A1BG, HADHA, ATP2A2, BDH1, ETFDH, HADHB, and CPT2 being reduced in common with both of fibrate-treated groups. The approach adopted in this study provides an efficient method for monitoring global changes in protein expression.
Journal
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 35 (1), 131-135, 2010
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390282679877107968
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- NII Article ID
- 10025983590
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- NII Book ID
- AN00002808
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- ISSN
- 18803989
- 03881350
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- NDL BIB ID
- 10578874
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed
