Chemical fate and mutagenic formation potentials of phenothiazine and related compounds during water chlorination
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- Sekizawa Taro
- Faculty of Pharmaceutical Sciences, Tokyo University of Science
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- Onodera Sukeo
- Faculty of Pharmaceutical Sciences, Tokyo University of Science
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The reactions of hetero-tricyclic aromatic hydrocarbons (H-TCAHs) with hypochlorite in an aqueous solution were investigated under conditions that simulate wastewater disinfection. H-TCAH-hypochlorite reaction products were determined by gas chromatographic-mass spectrometric (GC-MS) analyses. For 20 µM, 10H-phenothiazine, 10H-phenoxazine, and phenoxathiin reacted rapidly with active chlorine in neutral pH (7.0), but no phenazine-hypochlorite reaction was observed over pH values of 5-9 for 1 hr. The 10H-phenothiazine-hypochlorite reaction began by oxidation with active chlorine to form its dioxides, followed by chloro-substitution in water. The extent of the reactions depended on the chlorine dose, solution pH and compound structures. Ames assays for the chlorination byproducts of 10H-phenothiazine and 10H-phenoxazine also showed to be weak mutagenicity in TA98 and TA100 strains without S9 mix, but no chlorination byproducts of phenoxathiin exhibited any mutagenicity in both tester strains with and without S9 mix.
収録刊行物
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 35 (6), 853-862, 2010
一般社団法人 日本毒性学会
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詳細情報 詳細情報について
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- CRID
- 1390282679877482112
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- NII論文ID
- 10026963074
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- NII書誌ID
- AN00002808
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- ISSN
- 18803989
- 03881350
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- NDL書誌ID
- 10931785
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可