EFFECTS OF FORMALIN-PRESERVATION ON ELEMENT CONCENTRATIONS IN ANIMAL TISSUES
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- SATO Itaru
- Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
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- SERA Koichiro
- Cyclotron Research Center, Iwate Medical University
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- SUZUKI Tadahiko
- Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
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- KOBAYASHI Haruo
- Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
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- TSUDA Shuji
- Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
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Abstract
Determination of the exposure level of environmental pollutants is essential in studies on environmental toxicology. If concentrations of exposed pollutants in tissues are not affected by formalin-preservation, a preserved specimen will provide not only histopathological information but also the exposure level of environmental pollutants. In the present study, concentrations of nine elements in the liver and kidney were compared between fresh and formalin- or neutral formalin-preserved specimens to validate the ultimate analysis of the preserved specimens. After one year of preservation, various elements had diffused from the specimens into the solutions. The concentrations of iron, copper, zinc (in the case of neutral formalin) and selenium in the central region of the specimens showed no alterations, suggesting that the diffusions of these elements were limited to the surface of the specimens. Therefore, preserved specimens may be available for the determination of these elements if the specimens are large enough for their surface to be removed. Concentrations of other elements in the preserved specimens were different from the original ones, because the diffusion or infiltration also occurred in the deep region of the specimens.<br>
Journal
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 31 (3), 191-195, 2006
The Japanese Society of Toxicology
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Keywords
Details 詳細情報について
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- CRID
- 1390282679878073856
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- NII Article ID
- 110004814974
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- NII Book ID
- AN00002808
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- ISSN
- 18803989
- 03881350
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- NDL BIB ID
- 8079480
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed