Effect of an angiotensin II receptor blocker and a calcium channel blocker on hypertension associated penile dysfunction in a rat model
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- SHIMIZU Shogo
- Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Japan
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- TSOUNAPI Panagiota
- Division of Urology, Tottori University School of Medicine, Yonago, Japan
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- HONDA Masashi
- Division of Urology, Tottori University School of Medicine, Yonago, Japan
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- DIMITRIADIS Fotios
- B’ Urologic Department, Papageorgiou General Hospital, School of Medicine, Aristotle University, Thessaloniki, Greece
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- TANIUCHI Keisuke
- Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Japan
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- SHIMIZU Takahiro
- Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Japan
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- INOUE Keiji
- Department of Urology, Kochi Medical School, Kochi University, Nankoku, Japan
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- SAITO Motoaki
- Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Japan
書誌事項
- 公開日
- 2014
- 資源種別
- journal article
- DOI
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- 10.2220/biomedres.35.215
- 公開者
- バイオメディカルリサーチプレス
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説明
Possible effect of olmesartan, an angiotensin II receptor blocker (ARB), or nifedipine, an L-type calcium channel blocker, on penile dysfunction in the spontaneously hypertensive rat (SHR) was investigated in this study. Twelve-week-old male SHRs were treated with olmesartan (1 or 3 mg/kg, per orally (p.o.)) or nifedipine (30 mg/kg, p.o.) once a day for 6 weeks. Wistar rats and SHRs with vehicle treatment were used as controls. Penile cGMP and malondialdehyde concentrations, and mRNA levels of endothelial and neuronal NO synthase (eNOS and nNOS) were measured. Penile function was evaluated by organ bath studies with norepinephrine-induced contractions and acetylcholine-induced relaxations. The SHR showed significantly increased blood pressure, decreased cGMP concentrations, increased malondialdehyde concentrations, decreased eNOS and nNOS mRNA levels, norepinephrine-induced hyper-contractions, and acetylcholine-induced hyporelaxations in the penile tissue compared to the Wistar rat. Both nifedipine and olmesartan significantly decreased blood pressure, increased cGMP and normalized the hyper-contractions and hypo-relaxations observed in the SHR group. However, not nifedipine but olmesartan improved the malondialdehyde concentrations and increased mRNA levels of eNOS and nNOS in the penis. Our results indicate that the hypertension-associated penile dysfunction might be treated with ARBs such as olmesartan better than calcium channel blockers, such as nifedipine.
収録刊行物
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- Biomedical Research
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Biomedical Research 35 (3), 215-221, 2014
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