Nrf2-DEPENDENT GENE EXPRESSIONS: A MOLECULAR TOXICOLOGICAL ASPECT
-
- NUMAZAWA Satoshi
- Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University
-
- YOSHIDA Takemi
- Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University
この論文をさがす
説明
Although NF-E2 related factor 2 (Nrf2) was found to be a transcriptional regulator that controls an expression of the β-globin gene, the notion is now widely accepted that this transfactor serves as a master regulator for the gene expression of a battery of proteins acting on anti-oxidative stress and detoxification of electrophiles. The function of Nrf2 that bears transcriptional activation depends solely on its nuclear localization, which is regulated by interaction with the cytosolic anchor protein Keap1 and its own turnover rate. In the present mini-review, we focus on the regulation of Nrf2 function and discuss the physiological and toxicological aspects of this transcriptional factor.<br>
収録刊行物
-
- The Journal of Toxicological Sciences
-
The Journal of Toxicological Sciences 29 (2), 81-89, 2004
一般社団法人 日本毒性学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679878869632
-
- NII論文ID
- 110001812860
-
- NII書誌ID
- AN00002808
-
- COI
- 1:CAS:528:DC%2BD2cXmslCgtrc%3D
-
- ISSN
- 18803989
- 03881350
-
- NDL書誌ID
- 6972740
-
- PubMed
- 15206576
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可