<i><b>Gm7325</b></i><b> is MyoD-dependently expressed in activated muscle satellite </b><b>cells </b>
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- TAKEI Daisuke
- Graduate School of Pharmaceutical Sciences, Kyoto University
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- NISHI Miyuki
- Graduate School of Pharmaceutical Sciences, Kyoto University Center for the Promotion of Interdisciplinary Education and Research, Kyoto University
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- FUKADA So-ichiro
- Graduate School of Pharmaceutical Sciences, Osaka University
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- DOI Masao
- Graduate School of Pharmaceutical Sciences, Kyoto University
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- OKAMURA Hitoshi
- Graduate School of Pharmaceutical Sciences, Kyoto University
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- UEZUMI Akiyoshi
- Tokyo Metropolitan Institute of Gerontology
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- ZHANG Lidan
- Graduate School of Pharmaceutical Sciences, Osaka University
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- YOSHIDA Morikatsu
- National Cerebral and Cardiovascular Center Research Institute
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- MIYAZATO Mikiya
- National Cerebral and Cardiovascular Center Research Institute
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- ICHIMURA Atsuhiko
- Graduate School of Pharmaceutical Sciences, Kyoto University Center for the Promotion of Interdisciplinary Education and Research, Kyoto University
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- TAKESHIMA Hiroshi
- Graduate School of Pharmaceutical Sciences, Kyoto University
Bibliographic Information
- Other Title
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- Gm7325 is MyoD-dependently expressed in activated muscle satellite cells
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Description
<p>The Gm7325 gene, bioinformatically identified in the mouse genome, encodes a small protein but has not been characterized until recently. Our gene expression analysis revealed that Gm7325 transcription is remarkably upregulated in injured skeletal muscle tissues. Activated satellite cells and immature myotubes were densely decorated with positive signals for Gm7325 mRNA in in situ hybridization analysis, while no obvious signals were observed in quiescent satellite cells and mature myofibers. In the 5’-flanking regions of mouse Gm7325 and its human homologue, conserved E-box motifs for helix-loop-helix transcription factors are repeatedly arranged around the putative promoter regions. Reporter gene assays suggested that MyoD, a master transcription factor for myogenesis, binds to the conserved E-box motifs to activate Gm7325 expression. Therefore, Gm7325, as a novel MyoD-target gene, is specifically induced in activated satellite cells, and may have an important role in skeletal myogenesis.</p>
Journal
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- Biomedical Research
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Biomedical Research 38 (3), 215-219, 2017
Biomedical Research Press
