Induction of mesothelioma in p53± mouse by intraperitoneal application of multi-wall carbon nanotube

DOI Web Site Web Site PubMed PubMed 被引用文献120件 参考文献32件 オープンアクセス
  • Takagi Atsuya
    Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences
  • Hirose Akihiko
    Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences
  • Nishimura Tetsuji
    Division of Environmental Chemistry, National Institute of Health Sciences
  • Fukumori Nobutaka
    Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
  • Ogata Akio
    Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
  • Ohashi Norio
    Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
  • Kitajima Satoshi
    Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences
  • Kanno Jun
    Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences

書誌事項

タイトル別名
  • Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube
  • Induction of mesothelioma in p53+/− mouse by intraperitoneal application of multi-wall carbon nanotube
公開日
2008
資源種別
journal article
DOI
  • 10.2131/jts.33.105
公開者
一般社団法人　日本毒性学会

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説明

Nanomaterials of carbon origin tend to form various shapes of particles in micrometer dimensions. Among them, multi-wall carbon nanotubes (MWCNT) form fibrous or rod-shaped particles of length around 10 to 20 micrometers with an aspect ratio of more than three. Fibrous particles of this dimension including asbestos and some man-made fibers are reported to be carcinogenic, typically inducing mesothelioma. Here we report that MWCNT induces mesothelioma along with a positive control, crocidolite (blue asbestos), when administered intraperitoneally to p53 heterozygous mice that have been reported to be sensitive to asbestos. Our results point out the possibility that carbon-made fibrous or rod-shaped micrometer particles may share the carcinogenic mechanisms postulated for asbestos. To maintain sound activity of industrialization of nanomaterials, it would be prudent to implement strategies to keep good control of exposure to fibrous or rod-shaped carbon materials both in the workplace and in the future market until the biological/ carcinogenic properties, especially of their long-term biodurability, are fully assessed.<br>

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