Ranitidine hydrochlorideのラットにおける周産期及び授乳期投与試験

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  • EFFECTS ON OFFSPRINGS INDUCED BY ORAL ADMINISTRATION OF RANITIDINE TO THE FEMALE RAT IN PERIAND POSTNATAL PERIODS

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A perinatal and postnatal study was carried out in the Crj :CD (SD) rats orally administered ranitidine hydrochloride, a histamine H2-receptor anagonist, at dose levels of 50, 200, and 800 mg/kg/day as base for a period of time from day 17 of gestation to day 21 after delivery. All pregnant rats were allowed to litter naturally, and the postnatal development of the offsprings was observed. In the 800 mg/kg group, the delivery rate was significantly decreased and offspring mortality during the lactation period showed a tendency to increase as compared with control, but the difference was not significant. No significant differences between the Control group and the treated groups were found in postnatal group and differentiation, behavior and reproductive ability of male and female offsprings.

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