Toxicity studies of a synthetic antioxidant, 2,2'-methlenebis(4-ethyl-6-tert-butylphenol) in rats 2. Uncoupling effect on oxidative phosphorylation of liver mitochondria.
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Effects of 2, 2'-methylenebis (4-ethyl-6-tert-butylphenol) (MBEBP) on hepatic mitochondrial oxidative phosphorylation in vitro, and on hepatic peroxisomal enzymes activities and microsomal mixed-function oxidase activities were studied. 1. A low concentration of MBEBP, less than 50μM, increased state 4 respiration and decreased state 3 respiration. However, a higher concentration of MBEBP, greater than 100μM, acted as a respiratory inhibitor. Therefore, MBEBP was found to act as an uncoupler of oxidative phosphorylation in rat liver mitochondria. 2. MBEBP significantly decreased peroxisomal enzymes, cyanide-insensitive palmitoyl-CoA oxidizing activity and catalase activity in the livers of rats fed 0.2, 1.0 or 5.0% MBEBP for 4 weeks. 3. In microsomal enzyme assay, NADPH cytochrome c reductase activity was significantly increased, however, cytochrome P-450, cytochrome b5 levels, aminopyrine N-demethylase and benzo [a] pyrene hydroxylase activities were not significantly increased in the livers of rats fed 1.0 or 5.0% MBEBP for 4 weeks. The weight loss and the decrease of serum triglyceride level observed in the MBEBP-treated rats seemed to be caused by its uncoupling effects, which might also be the cause of the testicular damage induced by MBEBP.
収録刊行物
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 18 (1), 49-55, 1993
一般社団法人 日本毒性学会
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詳細情報 詳細情報について
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- CRID
- 1390282679879654528
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- NII論文ID
- 110001805303
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- NII書誌ID
- AN00002808
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- COI
- 1:CAS:528:DyaK3sXisV2ms7g%3D
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- ISSN
- 18803989
- 03881350
- http://id.crossref.org/issn/03881350
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- PubMed
- 8474150
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 使用不可