THE EFFECT OF TESTOSTERONE PROPIONATE SUPPLEMENT ON TESTICULAR TOXICITY WITH THIAMPHENICOL IN MALE SPRAGUE-DAWLEY RATS
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- MAITA Keizo
- The Institute of Environmental Toxicology
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- KUWAHARA Maki
- The Institute of Environmental Toxicology
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- KOSAKA Tadashi
- The Institute of Environmental Toxicology
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- INUI Kosei
- Central Research Institute, Ishihara Sangyo Kaisha, Ltd.,
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- SUGIMOTO Kayoko
- Formerly, The Institute of Environmental Toxicology
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- KASHIMOTO Yukiko
- The Institute of Environmental Toxicology
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- TAKAHASHI Naofumi
- The Institute of Environmental Toxicology
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- HARADA Takanori
- The Institute of Environmental Toxicology
書誌事項
- タイトル別名
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- effect of testosterone propionate supplement on testicular toxicity with thiamphenicol in male Sprague Dawley rats
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説明
Testosterone propionate (TP) was supplemented to male rats for assessment of its ameliorating effect on testicular toxicity with thiamphenicol (TAP). A total of 20 male Sprague-Dawley rats were treated orally with TAP at 200 mg/kg/day for up to 4 weeks. In addition, 5 male rats were allotted to the control group receiving vehicle only. Ten of the 20 treated rats had a Silastic capsule® (containing about 80 mg of TP) implanted in the dorsal skin at Week 2 and assigned to the TAP-TP group, while the other 10 treated rats were in the TAP group. After Weeks 3 and 4, five of both treated groups were examined for weight and histology of the testis and accessory genital glands, and for staging analysis of the seminiferous tubules. The same parameters were also assessed in the control group after Week 4. Weights and morphology of the seminal vesicle and prostate recovered remarkably from the TAP toxicity after TP supplement. However, no ameliorating effects of TP were obtained for the testis in either weight, morphology, or staging analysis of the seminiferous tubules.<br>
収録刊行物
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 29 (3), 187-193, 2004
一般社団法人 日本毒性学会
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詳細情報 詳細情報について
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- CRID
- 1390282679879861504
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- NII論文ID
- 110001802923
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- NII書誌ID
- AN00002808
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- ISSN
- 18803989
- 03881350
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- NDL書誌ID
- 7080181
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- PubMed
- 15467268
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可