Insulin Secretion and Insulin Sensitivity in Ketosis Associated with Excess Soft Drink Consumption. Changes during Therapy.

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  • 清涼飲料水ケトーシスにおけるインスリン分泌能とインスリン感受性の検討　治療に伴う変化
  • Changes during Therapy
  • 治療に伴う変化

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We studied six cases of ketosis in obese NIDDM associated with excess soft drink consumption. In all six, diabetes mellitus was newly diagnosed. The HbA1c levels ranged from 10.4% to 12.8%. They were treated with insulin, and insulin therapy could ultimately be withdrawn in all cases. In one case, urinary C-peptide excretion clearly increased from 5μg/day, the pre-therapy level, to 37μg/day after the institution of insulin therapy. There was, however, no remarkable change in the other five cases. Tests for insulin sensitivity using steady state plasma glucose (SSPG) were performed in 4 cases before and after instituting insulin therapy. The SSPG improved markedly (322±87mg/dl→84±38mg/dl) following therapy. In conclusion, in cases of ketosis associated with soft drink consumption, insulin secretory function appears to be relatively decreased, while decreasedinsulin sensitivity seems to further accelerate metabolic derangements. Following insulin therapy, insulin sensitivity is uniformly restored, but the restoration of insulin secretion as assessed by urinary C-peptide excretion varies among cases.

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