Clinical Characteristics of Slowly Progressive Insulin-Dependent (Type 1) Diabetes Mellitus (SPIDDM): 1st Subcommittee Report on SPIDDM, Committee on Type 1 Diabetes, Japan Diabetes Society

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  • Tanaka Shoichiro
    Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
  • Awata Takuya
    Department of Endocrinology and Diabetes, Saitama Medical University
  • Shimada Akira
    Department of Internal Medicine, Saiseikai Central Hospital
  • Murao Satoshi
    Diabetes Center, Takamatsu Hospital
  • Maruyama Taro
    Department of Internal Medicine, Saitama Social Insurance Hospital
  • Kamoi Kyuzi
    The Diabetes and Endocrine & Metabolism Disease Center, Nagaoka Red Cross Hospital
  • Kawasaki Eiji
    Department of Metabolism/Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry
  • Nakanishi Koji
    Department of Internal Medicine, Fuji Toranomon Orthopedic Hospital
  • Nagata Masao
    Department of Internal Medicine, Kakogawa Municipal Hospital
  • Fujii Sumie
    Diabetology & Endocrinology, Ishikawa Prefectural Central Hospital
  • Ikegami Hiroshi
    Department of Endocrinology, Metabolism and Diabetes, Kinki University School of Medicine
  • Imagawa Akihisa
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
  • Uchigata Yasuko
    Diabetes Center, Tokyo Women's Medical University School of Medicine
  • Okubo Minoru
    Department of Endocrinology and Metabolism, Toranomon Hospital
  • Osawa Haruhiko
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine
  • Kajio Hiroshi
    Department of Diabetes and Metabolic Medicine, National Center for Global Health and Medicine, Hospital
  • Kawaguchi Akio
    Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
  • Kawabata Yumiko
    Department of Endocrinology, Metabolism and Diabetes, Kinki University School of Medicine
  • Satoh Jo
    Department of Diabetes and Metabolism, Iwate Medical University
  • Shimizu Ikki
    Internal Medicine, Ehime Prefectural Imabari Hospital
  • Takahashi Kazuma
    Department of Diabetes and Metabolism, Iwate Medical University
  • Makino Hideichi
    Institute of Diabetes Research Center, Takanoko Hospital
  • Miura Junnosuke
    Diabetes Center, Tokyo Women's Medical University School of Medicine
  • Hanafusa Toshiaki
    First Department of Internal Medicine, Osaka Medical College
  • Kobayashi Tetsuro
    Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
  • Committee on Type 1 Diabetes

Bibliographic Information

Other Title
  • 緩徐進行１型糖尿病（ｓｌｏｗｌｙ　ｐｒｏｇｒｅｓｓｉｖｅ　ｉｎｓｕｌｉｎ‐ｄｅｐｅｎｄｅｎｔ　ｄｉａｂｅｔｅｓ　ｍｅｌｌｉｔｕｓ：ＳＰＩＤＤＭ）の臨床的特徴―日本糖尿病学会１型糖尿病調査研究委員会緩徐進行１型糖尿病分科会報告（第一報）―
  • 委員会報告 緩徐進行1型糖尿病(slowly progressive insulin-dependent diabetes mellitus:SPIDDM)の臨床的特徴--日本糖尿病学会1型糖尿病調査研究委員会緩徐進行1型糖尿病分科会報告(第1報)
  • イインカイ ホウコク カンジョ シンコウ 1ガタ トウニョウビョウ slowly progressive insulin dependent diabetes mellitus SPIDDM ノ リンショウテキ トクチョウ ニホン トウニョウビョウ ガッカイ 1ガタ トウニョウビョウ チョウサ ケンキュウ イインカイ カンジョ シンコウ 1ガタ トウニョウビョウ ブンカカイ ホウコク ダイ1ポウ

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To describe the clinical characteristics and prevalence of slowly progressive insulin-dependent (type 1) diabetes mellitus (SPIDDM), we conducted a nation-wide survey. We registered 687 diabetic patients with a history of diabetes of 5 years or less from April 2004 to December 2009 in our hospitals. Among them, 49 patients had SPIDDM, 425 patients had type 2 diabetes, and 58 patients had acute-onset type 1 diabetes. The frequency of SPIDDM patients was 10% (49/474, 95% confidence interval: 8-13%) among those with type 2 diabetes or SPIDDM. When compared with type 2 diabetic patients, SPIDDM patients showed significantly higher frequencies of autoimmune thyroid disease and insulin treatment at registration and significantly higher levels of HbA1c, and had significantly lower body mass index values. SPIDDM patients showed a significantly higher frequency of glutamic acid decarboxylase autoantibodies (GADAb) than insulinoma-associated protein 2 autoantibodies (IA-2Ab) or insulin autoantibodies (IAA), and showed a significantly higher frequency of single positive findings of autoantibodies among GADAb, IA-2Ab and IAA than patients with acute-onset type 1 diabetes. These results indicate that a high prevalence of SPIDDM was found in Japanese patients thought to have type 2 diabetes, and SPIDDM patients had specific clinical characteristics which differed from those with type 2 diabetes or acute-onset type 1 diabetes.<br>

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