グリメピリドが脂質代謝に及ぼす影響　　特にＳｍａｌｌ　ｄｅｎｓｅ　ＬＤＬについて

DOI Web Site 被引用文献2件 参考文献11件

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タイトル別名
  • Effects of Glimepiride on Lipid Metabolism, Especially in Small dense LDL.
  • グリメピリド ガ シシツ タイシャ ニ オヨボス エイキョウ : トクニ Small dense LDL ニ ツイテ
  • 特にSmall dense LDLについて

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抄録

We studied the effects of glimepiride on lipid metabolism compared to glibenclamide, focusing on small dense LDL related to both insulin resistance and atherosclerosis.Glimepiride therapy was started to 21 diabetic patients who had treated with glibenclamide. Two months after the regimen change, serum IRI significantly decreased (9.1±5.7 to 6.3±3.2, p<0.05), and LDL density decreased significantly (0.40±0.02 to 0.32±0.05, p<0.01) in 7 patients who had small dense LDL. These results suggested that glimepiride may increase LDL size, which would improve lipid metabolisrn and prevent the development of atherosclerosis.

収録刊行物

  • 糖尿病

    糖尿病 45 (7), 465-469, 2002

    一般社団法人 日本糖尿病学会

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