自殺目的でメトホルミンの多量内服後に乳酸アシドーシスと急性腎不全を発症した2型糖尿病の1例

書誌事項

タイトル別名
  • Type 2 Diabetes Mellitus with Lactic Acidosis and Acute Renal Failure Induced by Metformin Overdose in Suicide
  • ショウレイ ホウコク ジサツ モクテキ デ メトホルミン ノ タリョウ ナイフク ゴ ニ ニュウサン アシドーシス ト キュウセイ ジンフゼン オ ハッショウ シタ 2ガタ トウニョウビョウ ノ 1レイ

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説明

A 38-year-old man treated with oral metformin and insulin injection for type 2 diabetes mellitus since 5 years ago attempted on April 5, 2003, to kill himself by overdosing on metformin (26.25g) and was seen for nausea, vomiting, epigastralgia, and disturbance of consciousness.He was diagnosed with lactic acidosis and acute renal failure based on findings of elevated serum lactic acid (178.9 mg/dl), urea nitrogen (BUN)(128 mg/dl), and creatinine (11.8 mg/dl), and metabolic acidosis with a wide anion gap (anion gap 58.8, pH 7.219).Lactic acidosis and acute renal failure were improved by continuous hemodialysis filtration (CHDF) and intravenous fluid therapy.Diabetic control was improved by insulin therapy.After that, the patient was discharged.CHDF is recommended to treat metformin-induced lactic acidosis to maintain blood circulation.

収録刊行物

  • 糖尿病

    糖尿病 47 (6), 439-445, 2004

    一般社団法人 日本糖尿病学会

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