A Mathematical Approximation of the Beta-cell Response and the Peripheral Insulin Activity after Oral Glucose Loading
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- Kawai Atsuo
- The Institute For Adult Diseases, Asahi Life Foundation
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- Kuzuya Nobusada
- The Institute For Adult Diseases, Asahi Life Foundation
Bibliographic Information
- Other Title
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- 経ロブドウ糖負荷試験によるβ細胞分泌能および末梢インスリン活性の同時算定法に関する検討
- ケイコウ ブドウトウ フカ シケン ニヨル ベータ サイボウ ブンピノウ オヨ
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Abstract
We have re-examined Sluiter et al's report in which they proposed a mathematical approximation of two independent parameters, the beta-cell response and the peripheral insulin activity after 100g OGTT. It was confirmed that there exists a straight-line relationship between G and I/G for each individual during the early period after the glucose loading. Furthermore, we were able to deduce a very similar equation to theirs for the corrected insulin response as CIR = I30-100/G30 (G30-70) from the mean slope of the straight-line obtained from data of non-obese healthy subjects. There exists a definite correlation between CIR and insulinogenic index. Also, peripheral insuln activity (A) correlated well with insulin sensitivity indicies which were calculated from the speed of the blood glucose fall following a single intravenous injection of insulin.<BR>By these means, we have observed the following:<BR>1) The more obese person had a higher CIR and a smaller A.<BR>2) There were no specific differences in either of the parameters according to age and sex.<BR>3) CIR and A showed a concomitant decrease, as glucose tolerance diminished. In patients with diabetes mellitus, however, only CIR decreased further when FBS exceeded 120 mg/100 ml.<BR>4) Patients with chronic liver diseases revealed a significantly higher CIR and smaller A, when compared with control subjects who showed the same degree of glucose tolerance.<BR>5) 10 hrs after an oral administration of 2 mg dexamethasone, a significant decrease in A was observed, while 8 of 10 persons showed increases in CIR.
Journal
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- Journal of the Japan Diabetes Society
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Journal of the Japan Diabetes Society 20 (6), 720-727, 1977
THE JAPAN DIABETES SOCIETY
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Details 詳細情報について
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- CRID
- 1390282679880514432
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- NII Article ID
- 130004336635
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- NII Book ID
- AN00166576
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- ISSN
- 1881588X
- 0021437X
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- NDL BIB ID
- 1919217
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed