Monocomponent Insulinの抗原性に関する臨床的研究

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タイトル別名
  • Clinical Studies on Immunogenicity of Monocomponent Insulin
  • Monocomponent Insulin ノ コウゲンセイ ニ カンスル リ

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抄録

The immunogenicity of Monocomponent Insulin (MC-insulin) was studied in 7 non-insulin treated patients, 11 conventional insulin-treated patients and patients with an insulin allergy against con ventional insulin.<BR>The immunogenicity was estimated with serum insulin antibody titer and serum total insulin level during MC-insulin treatment and with serum IgE insulin antibody level and allergic phenomena in the patients with insulin allergy.<BR>In non-insulin treated patients, the treatment with MC-insulin provoked no significant elevation of antibody titer or total insulin level except in one case where the antibody and total insulin level rapidly elevated and showed no tendency to decrease even after one year's treatment with MCinsulin.<BR>The patients previously treated with conventional insulin (C-insulin) were separated into two groups one group was treated with MC-insulin and the other group was treated with C-insulin for one year. The antibody titer and insulin level decreased significantly in the patients treated with MC-insulin except in one case, but no change or a slight increase was observed in patients treated with C-insulin.<BR>The one case with insulin allergy treated with MC-insulin showed a decrease of antibody titer and IgE antibody level and allergic symptoms subsided gradually. But the other cases with insulin allergy showed no decrease of antibody titer and IgE antibody level even after one year of treatment with MC-insulin and allergic symptoms still persisted.<BR>From the above results, it is concluded that Monocomponent insulin has a low antigenicity as compared to conventional insulins but still has a weak antigenicity in some sensitive patients.

収録刊行物

  • 糖尿病

    糖尿病 20 (6), 711-719, 1977

    一般社団法人 日本糖尿病学会

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