SU剤長期使用時の効果と体重の増減について

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タイトル別名
  • The Relationship between the Change in Body Weight and the Effect of Long-term Treatment with Sulfonylurea Drugs
  • SUザイ チョウキ シヨウジ ノ コウカ ト タイジュウ ノ ゾウゲン ニ ツ

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抄録

In the long-term treatment of diabetic patients with sulfonylurea (SU) drugs, some patients require increasingly large doses of the drug, probably because of the failure of dietary treatment. In 97 diabetic patients who received the same SU drug for 5-7 years, we have followed changes in body weight as an indication of the efficiency of dietary treatment, and have investigated the relationship between the change in body weight, the dosage of the SU drug, and the degree of control of blood sugar levels.<BR>The three SU drugs employed were Glycodiazine, Glyclopyramide, and Glibenclamide. To evaluate the long-term effect of these drugs, the patients were classified into three groups according to the effect of the drug in controlling blood sugar levels in the first and second halves of the treatment period. In group I, the effect was maintained in the second half of the treatment period; in group II, the effect decreased partially ; and in group III, the drug became ineffective in the second half of the treatment period. The numbers of patients in each group whose weight increased or decreased, and the average degree of obesity in each group, were compared between the first and second halves of the treatment period.<BR>For the numbers of cases in each SU drug, group I was largest and group III smallest, showing that treatment with the same drug is possible for a long period. Also, for each drug, the numbers of patients who lost weight was greatest in group I, and the degree of obesity decreased in the second half of the treatment period in group I, while groups II and III showed no significant difference. These results suggest that the effect of SU drugs is maintained in patients whose body weight decreases toward normal with a correctly miantained diet.

収録刊行物

  • 糖尿病

    糖尿病 20 (6), 689-693, 1977

    一般社団法人 日本糖尿病学会

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