10年以上投与55例を含むSU剤投与長期使用群における血管合併症の進展について

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タイトル別名
  • Development of Vascular Complications in the Diabetics Treated with Sulfonylurea for Long Term.
  • 10ネン イジョウ トウヨ 55レイ オ フクム SUザイ トウヨ チョウキ

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抄録

In order to evaluate the influence of long-term sulfonylurea therapy on the development of vascular complications (ECG abnormality, retinopathy and albuminuria) a study was made on 236 diabetic patients during a period of treatment which extended from 3 years to 18 years.<BR>165 patients were treated with sulfonylurea (SU-group), 23 patients with insulin (I-group) and 48 patients by diet alone.<BR>None of the patients had ever received any diabetic therapy.<BR>No significant difference was found in the frequency of ECG abnormality in the SU-group between the results before and after SU treatment.<BR>The frequency of ECG abnormarity in the I-group was higher than in the SU-group at 5 years and at 10 years, but this difference was not statistically significant.The frequency of retinopathy was significantly higher in the I-group than in the SU-group at 5 years and at 10 years.<BR>There was no significant difference among the three groups in the frequency of albuminuria.<BR>The appearance and the development of vascular lesions were examined in 55 patients who had been treated with SU for 10 years and in 11 patients who had been treated with insulin for 10 years continuously.<BR>The rate of appearance of ECG abnormality in the SU-group increased gradually during the 1 years follow up, however it increased rapidly in the I-group after 4 years, and it was found to be more significant in the I-group than in the SU-group at 7, 9 and 10 years.<BR>The rate of abvance of retinopathy was high at 5 years in the SU-group and was stable thereafter.<BR>On the other hand the rate of advance of retinopathy in the I-group was elevated step-wise after 5 years follow up, and at 9 and 10 years it was significantly higher in the insulin than in the SUgroup.<BR>The incidence of albuminuria in both groups was elevated after 8 years.<BR>These findings showed that the frequency and the development of vascular complications in the SU-group were lower than that in the I-group during long term treatment.

収録刊行物

  • 糖尿病

    糖尿病 20 (6), 694-700, 1977

    一般社団法人 日本糖尿病学会

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