Ninjinyouei-to (TJ-108), a Chinese Medicine Containing Polygalae Radix, Increases the Blood Concentration of 1,5-anhydro-D-glucitol Independent of That of Glucose and HbA1C in Diabetic Patients.

Tatsuno Ichiro, Noguchi Yoshihiko, Tanaka Tomoaki, Nakamura Susumu, Uchida Daigaku, Hirai Aizan, Saito Yasushi

doi:10.11213/tonyobyo1958.45.583

Bibliographic Information

Other Title

オンジを多く含む漢方薬（人参養栄湯）の血清１，５アンヒドログルシトール（１，５ＡＧ）値に及ぼす影響　　健常人および糖尿病患者での検討
オンジオオオクフクムカンポウヤク(ニンジンヨウエイユ)ノケッセイ 1,5 アンヒドログルシトール(1,5AG)アタイニオヨボスエイキョウ : ケンジョウジンオヨビトウニョウビョウカンジャデノケントウ
健常人および糖尿病患者での検討

Search this article

Description

The blood concentration of 1, 5-anhydro-D-glucitol (1, 5-AG) has been used asa marker for diabetic control. In diabetic patients, high urine glucose competes the absorption of1, 5-AG at renal tubules and lowers its blood concentration. In general, the major source of 1, 5-AG is food and daily in take was reported to be relatively stable in Japan. Although Chinese medicines have been traditionally and widely used for many kinds of disease, it is less known well that one of their components, especially polygalae radix, contains large amounts of 1, 5-AG. We examined the effect of an extract of polygalae radix and ninjinyouei-to (TJ-108) on the blood concentration of 1, 5-AG in 5 healthy volunteers and 13 patients including those with diabetes mellitus.We found that both the extract of polygalae radix and TJ-108 increase 1, 5-AG without affecting glucose metabolism.Chinese medicines containing polygalae radix should thus be better evaluated in 1, 5-AG blood concentration as a marker of diabetic control.

Journal

Journal of the Japan Diabetes Society

Journal of the Japan Diabetes Society 45 (8), 583-587, 2002

THE JAPAN DIABETES SOCIETY

Keywords

Details 詳細情報について

Export