Extrapancreatic Effect of 7-Consecutive-day Oral Administration of Glimepiride, a Newly Developed Sulfonylurea, on Hepatic Glucose Disposal in Healthy Dogs.

DOI

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Other Title
  • Ｇｌｉｍｅｐｉｒｉｄｅ（ＨＯＥ４９０）のすい外作用　肝ブドウ糖取り込みに及ぼすｇｌｉｍｅｐｉｒｉｄｅ１週間反復経口投与の効果
  • 肝ブドウ糖取り込みに及ぼすglimepiride 1週間反復経口投与の効果

Abstract

The extrapancreatic effect of glimepiride on hepatic glucose disposal was quantitatively investigated in seven healthy dogs using a euglycemic hyperinsulinemic clamp combined with the hepatic venous catheterization technique. Euglycemic clamping (EC) was performed by peripheral infusion of somatostatin and glucose and intraportal infusion of insulin for 180 minutes, prior to and after 7 day admisistration of glimepiride (0.1 mg/kg/day). During the latter half of each clamp, glucose was simultaneously infused intraportally at a rate of 7 mg/kg · min. After glimepiride treatment, 1) fasting plasma IRI levels increased significantly, and plasma glucose concentrations decreased significantly (p<0.05), 2) during the first 90 min of the EC, systemic glucose utilization significantly increased (8.2±0.7 vs. 11.6±1.3 mg/kg·min, mean±SEM, p<0.05), but there was no change in hepatic glucose uptake, 3) during the second 90 min of the EC, there was a remakable increase in the hepatic glucose disposal (net hepatic glucose balance, 2.2±0.5 vs. 5.8±1.0 mg/kg·min, p<0.05).<BR>These data indicate that insulin-stimulated hepatic glucose disposal is markedly augmented by 7 day glimepiride treatment when glucose is loaded via a physiological route.

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Details 詳細情報について

  • CRID
    1390282679880714240
  • NII Article ID
    130004115169
  • DOI
    10.11213/tonyobyo1958.38.447
  • COI
    1:CAS:528:DyaK2MXnsl2gsrg%3D
  • ISSN
    1881588X
    0021437X
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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