Immunological Insulin Resistance to Human Insulin/Insulin Aspart and Effective Treatment with Insulin Lispro in a Patient with Type 2 Diabetes
-
- Kubo Tadashi
- Department of Internal Medicine, Kamiichi General Hospital
-
- Goto Rie
- Department of Internal Medicine, Kamiichi General Hospital
-
- Takagi Masatoshi
- Department of Pharmacy, Kamiichi General Hospital
Bibliographic Information
- Other Title
-
- ヒトインスリン/インスリンアスパルトへの重篤なインスリン抵抗性が生じ,インスリンリスプロが著効した2型糖尿病の1例
- ヒトインスリン/インスリンアスパルトへの重篤なインスリン抵抗性が生じ,インスリンリスプロが著効した2型糖尿病の1例--抗体の質的検討
- ヒトインスリン インスリンアスパルト エノ ジュウトクナ インスリン テイコウセイ ガ ショウジ インスリン リスプロ ガ チョコウシタ 2ガタ トウニョウビョウ ノ 1レイ コウタイ ノ シツテキ ケントウ
- —抗体の質的検討—
- —Qualitative Analysis of Insulin Antibodies—
Search this article
Description
An 84-year-old man with type 2 diabetes treated with human insulin from April 2000 to January 2003 experienced a progressive daily insulin dose increase up to 80 U/day during this period and 125I-insulin binding was 96%. His regimen was converted from human insulin to almost the same dose of insulin aspart. In July 2004, his blood glucose rose abruptly (FBG>300 mg/dl) and could not be controlled even with more than 90 units of insulin aspart. We then treated him with insulin lispro, after which his blood glucose rapidly decreased and was well controlled with 12 U of insulin lispro 3 times daily before each meal. We found that insulin antibodies specific to insulin aspart were 15.1% and cross-reacting to human insulin/insulin aspart were 47.2%.<br>Scatchard analysis of insulin antibodies showed a low-affinity constant and an extremely high binding capacity of high-affinity sites. Insulin antibody binding resembled that in insulin autoimmune syndrome. We concluded that he developed severe immunological insulin resistance caused mainly by antibodies cross-reacting to human insulin/insulin aspart. Insulin lispro seemed less reactive to his antibodies and was effective for his glycemic control.
Journal
-
- Journal of the Japan Diabetes Society
-
Journal of the Japan Diabetes Society 50 (2), 145-152, 2007
THE JAPAN DIABETES SOCIETY
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390282679881211136
-
- NII Article ID
- 10018870368
-
- NII Book ID
- AN00166576
-
- ISSN
- 1881588X
- 0021437X
-
- NDL BIB ID
- 8736177
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- NDL
- CiNii Articles
-
- Abstract License Flag
- Disallowed