２型糖尿病患者の抗酸化能と血しょうヒドロペルオキシド

DOI

書誌事項

タイトル別名
  • Total Plasma Antioxidant Capacity and Hydroperoxide in Patients with Type 2 Diabetes Mellitus.

抄録

We studied the relationship between total antioxidant capacity (TAOC) and hydroperoxide (HPO) in plasma from 165 patients with type 2 diabetes mellitus, and the influence on TAOC by plasma glucose. Control subjects were 78 age-gender ratio-matched individuals.In the diabetes group, TAOC correlated negatively with HPO (r=-0.414, p<0.0001). TAOC was significantly lower in the diabetes group than in the control group (p=0.0130), and HPO was significantly higher in the diabetes group than in the control group (p<0.0001). Multiple regression analysis using TAOC as the object variable and various factors as explanatory showed that serum uric acid was strongly positively significant (β=0.665, p<0.0001), and that fasting plasma glucose was a negatively significant (p=-0.118, p=0.0403) independent contributing factor. These results show that consumption of antioxidant molecules in plasma by hyperglycemia causes higher HPO and may constitute a risk factor for atherosclerosis.

収録刊行物

  • 糖尿病

    糖尿病 45 (10), 731-736, 2002

    一般社団法人 日本糖尿病学会

キーワード

詳細情報 詳細情報について

  • CRID
    1390282679881326848
  • NII論文ID
    130004115335
  • DOI
    10.11213/tonyobyo1958.45.731
  • ISSN
    1881588X
    0021437X
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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