書誌事項
- タイトル別名
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- Elevated High-sensitivity C-reactive Protein Correlates with Insulin Resistance and Hyper-E-selectinemia in Patients with Type 2 Diabetes.
- 2ガタ トウニョウビョウ ニ オケル コウカンド C-reactive protein タカネ ノ イギ : インスリン テイコウセイ オヨビ セッチャク ブンシ E-セレクチン ト ノ カンレンセイ
- インスリン抵抗性および接着分子E-セレクチンとの関連性
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抄録
High-sensitivity C-reactive protein (hs-CRP) was recently identified as an independent predictor of atherosclerotic vascular disease. The physiological significance of elevated hs-CRP remains to be evaluated, however. To determine the relationship between hs-CRP and insulin resistance and serum E-selectin, an endothelial activation marker, we conducted a case-control study of 45 diabetic patients with high hs-CRP (≥ 0.10 mg/dl) and 45 age-and gender-matched diabetic patients with low hs-CRP (≤0.03 mg/dl). Patients with high hs-CRP had a significantly greater body mass index and triglycerides, and significantly lower HDL cholesterol. Insulin sensitivity, measured by the K index of the insulin tolerance test (Kitt), was significantly lower in patients with high hs-CRP than in those with low hs-CRP (2.29 ± 0.88 vs. 2.82 ± 1.11%/min, mean ± SD, p<0.05). The mean soluble adhesion molecule, E-selectin, was significantly higher in patients with high hs-CRP than in those with low hs-CRP (70.9 ± 29.8 vs. 55.4 ± 30.8 ng/ml, p<0.01). Our results indicate that elevated hs-CRP in patients with type 2 diabetes reflect the presence of insulin resis tance and endothelial activation.
収録刊行物
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- 糖尿病
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糖尿病 46 (1), 1-5, 2003
一般社団法人 日本糖尿病学会
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詳細情報 詳細情報について
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- CRID
- 1390282679881853312
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- NII論文ID
- 10010739830
- 130004338876
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- NII書誌ID
- AN00166576
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- ISSN
- 1881588X
- 0021437X
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- NDL書誌ID
- 025094099
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可