Combined repeated dose and reproductive/developmental toxicity screening test of tert-butylhydrazine monohydrochloride in rats
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- Kobayashi Toshio
- CERI Hita, Chemicals Evaluation and Research Institute, Japan
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- Aso Sunao
- CERI Hita, Chemicals Evaluation and Research Institute, Japan
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- Koga Takayuki
- CERI Hita, Chemicals Evaluation and Research Institute, Japan
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- Hoshuyama Satsuki
- CERI Hita, Chemicals Evaluation and Research Institute, Japan
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- Oshima Yutaka
- CERI Hita, Chemicals Evaluation and Research Institute, Japan
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- Miyata Katsumi
- CERI Hita, Chemicals Evaluation and Research Institute, Japan
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- Kusune Yuji
- CERI Hita, Chemicals Evaluation and Research Institute, Japan
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- Muroi Takako
- CERI Hita, Chemicals Evaluation and Research Institute, Japan
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- Yoshida Tomohiko
- Chemical Biotesting Center, Chemicals Evaluation and Research Institute, Japan
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- Hasegawa Ryuichi
- Chemical Biotesting Center, Chemicals Evaluation and Research Institute, Japan
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- Ajimi Syozo
- CERI Hita, Chemicals Evaluation and Research Institute, Japan
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- Furukawa Kotaro
- CERI Hita, Chemicals Evaluation and Research Institute, Japan
書誌事項
- タイトル別名
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- Combined repeated dose and reproductive/developmental toxicity screening test of <i>tert</i>-butylhydrazine monohydrochloride in rats
この論文をさがす
抄録
tert-Butylhydrazine monohydrochloride was daily administered by gavage to groups of Crl:CD (SD)IGS rats at doses of 0 (control), 0.8, 4, or 20 mg/kg/day. Twelve males per group were treated for a total of 42 days from 14 days before mating. Twelve females per group were treated from 14 days before mating to day 4 of lactation throughout the mating and gestation periods. Recovery groups of five males and five non-pregnant females per group were dosed for 42 days followed by a 14-day recovery period. No deaths were observed in any groups of either sex. There were no considerable changes in body weight, food intake, general appearance, functional observations or biochemical analysis. Values of the anemic parameters were decreased in the 20 mg/kg/day males and in all female dose groups. The relative weight of the liver, kidneys and spleen was significantly increased in 20 mg/kg/day females. Histopathological examination showed congestion and hemosiderin deposition in the spleen at 20 mg/kg/day in both sexes, but there were no changes in the liver or kidneys in either sex. Anemic parameters with hemosiderin deposition did not completely recover in the 20 mg/kg/day group in both sexes after the recovery period. As for reproduction, a significant reduction was only observed in the number of corpora lutea at 20 mg/kg/day. It was thus concluded that the LOAEL was 0.8 mg/kg/day based on the decreased values of the anemic parameters of repeated-dose toxicity, and that the NOAEL was 4 mg/kg/day based on the low number of corpora lutea of reproductive/developmental toxicity.
収録刊行物
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 38 (2), 177-192, 2013
一般社団法人 日本毒性学会
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詳細情報 詳細情報について
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- CRID
- 1390282679881894656
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- NII論文ID
- 10031151422
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- NII書誌ID
- AN00002808
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- COI
- 1:CAS:528:DC%2BC3sXnt12qt7g%3D
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- ISSN
- 18803989
- 03881350
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- NDL書誌ID
- 024644841
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- PubMed
- 23535397
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可