Changes in <SUP>125</SUP>I-insulin Binding Antibodies in Diabetic Pregnant Women on Insulin Therapy and Hypoglycemia in Newborns
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- Kohama Tomoko
- Diabetes Center, Tokyo Women's Medical College
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- Omori Yasue
- Diabetes Center, Tokyo Women's Medical College
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- Minei Satomi
- Diabetes Center, Tokyo Women's Medical College
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- Akihisa Rima
- Diabetes Center, Tokyo Women's Medical College
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- Honda Masashi
- Diabetes Center, Tokyo Women's Medical College
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- Hirata Yukimasa
- Diabetes Center, Tokyo Women's Medical College
Bibliographic Information
- Other Title
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- インスリン治療糖尿病妊婦における`125´I‐インスリン結合抗体の推移と新生児低血糖
- インスリン チリョウ トウニョウビョウ ニンプ ニ オケル 125I インスリ
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Description
To elucidate whether insulin antibodies in pregnant diabetics are related to changes in insulin requirement during pregnancy, and whether hypoglycemia in newborns of diabetic mothers is influenced by insulin antibodies transferred through the placenta, changes in 125I-insulin percent binding to insulin antibodies were measured at the first, second and third trimesters of pregnancy and at delivery, in 20 deliveries by 17 diabetics treated with insulin.<BR>The free insulin levels in the same serum were also measured for each patient in whom the 125I-insulin binding was decreased more than 5% in the third trimester.<BR>The mean percent of 125I-insulin binding in the 20 diabetic pregnancies was unchanged in the first (21.2%) and second trimester (21.1%), but tended to decrease to 17.6% in the third trimester and to increase to 24.6% after delivery.<BR>The 125I-insulin percent binding of 5 patients with neonatal hypoglycemia was significantly higher than that of the other patients without hypoglycemia (p<0.05).<BR>An increase of free insulin levels was observed in 5 of 11 patients in whom the 125I-insulin percent binding was decreased in the third trimester in contrastwith an increased insulin dosage.<BR>The finding that hypoglycemia tended to occur in the newborns of diabetic mothers with high insulin percent binding to insulin antibody during the third trimester, suggests that maternal insulin antibodies may affect the fetal pancreas.
Journal
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- Journal of the Japan Diabetes Society
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Journal of the Japan Diabetes Society 25 (8), 891-898, 1982
THE JAPAN DIABETES SOCIETY
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Details 詳細情報について
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- CRID
- 1390282679882187520
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- NII Article ID
- 130004337038
- 40002631647
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- NII Book ID
- AN00166576
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- ISSN
- 1881588X
- 0021437X
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- NDL BIB ID
- 2497182
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed