糖尿病性ケトアシドーシスを機にグリコーゲン蓄積による肝腫大をくり返した１型糖尿病の１例

DOI

書誌事項

タイトル別名
  • Recurrent Hepatomegaly Due to Glycogen Storage after Diabetic Ketoacidosis in a Case of Type 1 Diabetes Mellitus.

抄録

A 19-year-old woman, who had a history of type 1 diabetes mellitus since 15 years of age, was admitted to our hospital due to diabetic ketoacidosis (DKA) in November 1997. She had hepatomegaly and liver dysfunction on admission, but the abnormalities resolved after administration of insulin. However, marked hepatomegaly and liver dysfunction reappeared with hypoglycemia, hypokalemia, and leucocytopenia 4 weeks after DKA. Liver biopsy showed extensive glycogen deposition and mild steatosis. Her hepatomegaly disappeared in acoordance with a reduced insulin requirement 10 weeks after DKA. However, she showed recurrent hepatomegaly 5 months thereafter, consistent with poor diabetic control. In our case, glycogen storage may have been promoted by high concentrations of glucose, as well as pH change and release of glucose toxicity. Marked hepatomegaly caused by glycogen storage with type 1 diabetes mellitus is unusual. Thus, we speculate that such cases may have gene mutations in enzymes related to liver glycogen metabolism.

収録刊行物

  • 糖尿病

    糖尿病 43 (10), 879-885, 2000

    一般社団法人 日本糖尿病学会

キーワード

詳細情報 詳細情報について

  • CRID
    1390282679882311296
  • NII論文ID
    130004338619
  • DOI
    10.11213/tonyobyo1958.43.879
  • ISSN
    1881588X
    0021437X
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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