Toxicomics Report : Proteomic analysis of ethanol-induced embryotoxicity in cultured post-implantation rat embryos

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  • Usami Makoto
    Division of Pharmacology, National Institute of Health Sciences
  • Mitsunaga Katsuyoshi
    School of Pharmaceutical Sciences, Toho University
  • Irie Tomohiko
    Division of Pharmacology, National Institute of Health Sciences
  • Miyajima Atsuko
    Division of Medical Devices, National Institute of Health Sciences
  • Doi Osamu
    Laboratory of Animal Reproduction, United Graduate School of Agricultural Science, Gifu University

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  • Proteomic analysis of ethanol-induced embryotoxicity in cultured post-implantation rat embryos

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Protein expression changes were examined in day 10.5 rat embryos cultured for 24 hr in the presence of ethanol by using two-dimensional electrophoresis and mass spectrometry. Exposure to ethanol resulted in quantitative changes in many embryonic protein spots (16 decreased and 28 increased) at in vitro embryotoxic concentrations (130 and 195 mM); most changes occurred in a concentration-dependent manner. For these protein spots, 17 proteins were identified, including protein disulfide isomerase A3, alpha-fetoprotein, phosphorylated cofilin-1, and serum albumin. From the gene ontology classification and pathway mapping of the identified proteins, it was found that ethanol affected several biological processes involving oxidative stress and retinoid metabolism.

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