A Case of Pre-menopausal Type 2 Diabetes Women with Familial Type III Hyperlipoproteinemia Which Suspects Participation of a LPL Hetero Deficit and Had Coronary Lesion

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  • Miwa Kazuma
    Department of Diabetology & Endocrinology, Nagoya University Hospital Division of Endocrinology & Metabolism, Kainan Hospital
  • Haga Tatsuya
    Division of Endocrinology & Metabolism, Kainan Hospital
  • Nakamura Jiro
    Department of Diabetology & Endocrinology, Nagoya University Hospital

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  • リポ蛋白リパーゼヘテロ欠損症合併が疑われる閉経前発症III型高脂血症を有し, 冠動脈狭窄が認められた2型糖尿病の1例
  • 症例報告 リポ蛋白リパーゼヘテロ欠損症合併が疑われる閉経前発症3型高脂血症を有し,冠動脈狭窄が認められた2型糖尿病の1例
  • ショウレイ ホウコク リポ タンパク リパーゼヘテロ ケッソンショウ ガッペイ ガ ウタガワレル ヘイケイ ゼン ハッショウ 3ガタ コウシケツショウ オ ユウシ カンドウミャク キョウサク ガ ミトメラレタ 2ガタ トウニョウビョウ ノ 1レイ

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Abstract

A 48-year-old premenopausal woman diagnosed with mild dyslipidemia at 35 and type 2 diabetes mellitus at 45 and admitted in March 2003 was found to have severe dyslipidemia (total cholesterol, 421 mg/dl, triglyceride, 2,733 mg/dl) and lipoprotein electrophoresis showed a broad β pattern.<br>We diagnosed her with familial type III hyperlipoproteinemia (HLP) based on the apoE protein phenotype (E2/E2). She had complicated lower Lipoproreinlipase (LPL), fasting chyromicronemia, and coronary arteriostenosis. Premenopausal type III HLP patients are considered rare and Japanese type III HLP patients to have low plasma lipid.<br>We report this case of a premenopausal type III HLP patient with severe dyslipidemia and decreased LPL protein. We concluded that insulin resistance and decreased LPL protein play an important role in type III HLP onset and aggravation.

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