Increased antibody-dependent cell-mediated cytotoxicity of spleen lymphocytes from low-dose streptozotocin-induced diabetes in mice.
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- Maruyama Taro
- Department of Internal Medicine, School of Medicine, Keio University
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- Hattori Yoshiyuki
- Department of Internal Medicine, School of Medicine, Keio University
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- Asaba Yoshiaki
- Department of Internal Medicine, School of Medicine, Keio University
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- Baba Ryoko
- Department of Internal Medicine, School of Medicine, Keio University
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- Ikemoto Kumiko
- Department of Internal Medicine, School of Medicine, Keio University
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- Takei Izumi
- Department of Internal Medicine, School of Medicine, Keio University
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- Taniyama Matsuo
- Department of Internal Medicine, School of Medicine, Keio University
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- Kataoka Kunizo
- Department of Internal Medicine, School of Medicine, Keio University
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- Ishii Toshiharu
- Department of Pathology, School of Medicine, Keio University
Bibliographic Information
- Other Title
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- Streptozotocin少量ひん回投与糖尿病マウスのADCC活性
Description
Multiple low-dose streptozotocin-induced diabetes in mice is thought to be a model of type 1 (insulin-dependent) diabetes mellitus because it is associated with insulitis. Several investigators have reported that cell-mediated immune response, especially thymic immunity, plays a critical role in the development of this type of diabetes. However, there are no reports concerning antibodydependent cell-mediated cytotoxicity (ADCC) or K-cells. Therefore, we investigated the ADCC of spleen lymphocytes from streptozotocin-induced diabetic mice and compared them with blood glucose levels and insulitis.<BR>Eight-week-old male CD-1 +/+ mice and CD-1 nu/nu mice were studied. Among the CD-1 +/+ mice, increased ADCC and insulitis were found in multiple low-dose streptozotocin-injected mice before diabetes developed and the ADCC increased with the degree of insulitis. However, there was no insulitis or increased ADCC in single high-dose streptozotocin-injected mice or control mice. Among the CD-1 nu/nu mice, increased ADCC and high blood glucose levels were found but there was no insulitis in multiple low-dose streptozotocin-injected mice.<BR>These results suggest that increased ADCC is connected with multiple low-dose streptozotocin injection and may play a pathogenetic role in the development of insulitis in the presence of thymic immunity. Our results also suggest that insulitis enhances the diabetogenic effect of streptozotocin.
Journal
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- Journal of the Japan Diabetes Society
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Journal of the Japan Diabetes Society 29 (5), 425-431, 1986
THE JAPAN DIABETES SOCIETY
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Details 詳細情報について
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- CRID
- 1390282679882683392
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- NII Article ID
- 130004337396
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- ISSN
- 1881588X
- 0021437X
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed