Cerebral cortex and hippocampus respond differently after post-natal exposure to uranium
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- Lestaevel Philippe
- Institut de RadioProtection et de Sûreté Nucléaire, Pôle de la Radioprotection de l’Homme, Service de Radiobiologie et d’Epidémiologie, Laboratoire de Radiotoxicologie Expérimentale
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- Bensoussan Hélène
- Institut de RadioProtection et de Sûreté Nucléaire, Pôle de la Radioprotection de l’Homme, Service de Radiobiologie et d’Epidémiologie, Laboratoire de Radiotoxicologie Expérimentale
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- Dhieux Bernadette
- Institut de RadioProtection et de Sûreté Nucléaire, Pôle de la Radioprotection de l’Homme, Service de Radiobiologie et d’Epidémiologie, Laboratoire de Radiotoxicologie Expérimentale
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- Delissen Olivia
- Institut de RadioProtection et de Sûreté Nucléaire, Pôle de la Radioprotection de l’Homme, Service de Radiobiologie et d’Epidémiologie, Laboratoire de Radiotoxicologie Expérimentale
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- Vacher Claire-Marie
- Laboratoire de Neuroendocrinologie Moléculaire de la Prise Alimentaire, UMR 1197 INRA/Université Paris XI
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- Dublineau Isabelle
- Institut de RadioProtection et de Sûreté Nucléaire, Pôle de la Radioprotection de l’Homme, Service de Radiobiologie et d’Epidémiologie, Laboratoire de Radiotoxicologie Expérimentale
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- Voisin Philippe
- Institut de RadioProtection et de Sûreté Nucléaire, Pôle de la Radioprotection de l’Homme, Service de Radiobiologie et d’Epidémiologie, Laboratoire de Radiotoxicologie Expérimentale
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- Taouis Mohammed
- Laboratoire de Neuroendocrinologie Moléculaire de la Prise Alimentaire, UMR 1197 INRA/Université Paris XI
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The central nervous system (CNS) is known to be sensitive to pollutants during its development. Uranium (U) is a heavy metal that occurs naturally in the environment as a component of the earth’s crust, and populations may therefore be chronically exposed to U through drinking water and food. Previous studies have shown that the CNS is a target of U in rats exposed in adulthood. We assessed the effects of U on behavior and cholinergic system of rats exposed from birth for 10 weeks at 10 mg.L-1 or 40 mg.L-1. For behavioral analysis, the sleep/wake cycle (recorded by telemetry), the object recognition memory and the spatial working memory (Y-maze) were evaluated. Acetylcholine (ACh) and acetylcholinesterase (AChE) levels were evaluated in the entorhinal cortex and hippocampus. At 40 mg.L-1, U exposure impaired object recognition memory (-20%), but neither spatial working memory nor the sleep/wake cycle was impaired. A significant decrease was observed in both the ACh concentration (-14%) and AChE activity (-14%) in the entorhinal cortex, but not in the hippocampus. Any significant effect on behaviour and cholinergic system was observed at 10 mg U.L-1. These results demonstrate that early exposure to U during postnatal life induces a structure cerebral-dependant cholinergic response and modifies such memory process in rats. This exposure to U early in life could have potential delayed effects in adulthood.
収録刊行物
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 38 (5), 803-811, 2013
一般社団法人 日本毒性学会
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詳細情報 詳細情報について
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- CRID
- 1390282679882864768
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- NII論文ID
- 10031191740
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- NII書誌ID
- AN00002808
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- COI
- 1:CAS:528:DC%2BC3sXhslyitbrF
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- ISSN
- 18803989
- 03881350
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- NDL書誌ID
- 024934444
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- PubMed
- 24067729
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可