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- Tomita Mariko
- Institute of Environmental Toxicology
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- Yoshida Toshinori
- Institute of Environmental Toxicology
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- Fukumori Junko
- Institute of Environmental Toxicology
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- Yamaguchi Satoru
- Institute of Environmental Toxicology
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- Kojima Sayuri
- Institute of Environmental Toxicology
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- Fukuyama Tomoki
- Institute of Environmental Toxicology
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- Ohnuma-Koyama Aya
- Institute of Environmental Toxicology
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- Takahashi Naofumi
- Institute of Environmental Toxicology
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- Takeuchi-Kashimoto Yukiko
- Institute of Environmental Toxicology
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- Kuwahara Maki
- Institute of Environmental Toxicology
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- Nakashima Nobuaki
- Institute of Environmental Toxicology
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- Ohtsuka Ryoichi
- Institute of Environmental Toxicology
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- Takeda Makio
- Institute of Environmental Toxicology
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- Kosaka Tadashi
- Institute of Environmental Toxicology
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- Harada Takanori
- Institute of Environmental Toxicology
書誌事項
- タイトル別名
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- <i>p</i>,<i>p</i>′-DDT induces microcytic anemia in rats
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抄録
Emerging evidence suggests that chronic exposure to DDT and its derivatives is associated with a variety of human disorders such as anemia. The present study demonstrated that p,p′-DDT caused microcystic anemia in a dose-dependent manner (0, 5, 50, and 500 ppm) in the long-term study up to 2 years. To elucidate the mechanism(s) by which p,p′-DDT induces anemia, certain hematological parameters were assessed in rats fed specific doses of p,p′-DDT for 2 weeks, and the effect of lipopolysaccharide on anemia of inflammation was also examined in p,p′-DDT-treated rats. The parameters included the content of hemoglobin per reticulocyte, mean corpuscular volume of reticulocytes and mature erythrocytes, corpuscular hemoglobin concentration mean of mature erythrocytes, and saturation levels of transferrin and iron. During the 2-week treatment period, hypochromic microcytic reticulocytes and hypochromic normocytic mature erythrocytes were observed in p,p′-DDT-treated rats, with no evidence of alteration in plasma iron levels. p,p′-DDT enhanced microcytosis of reticulocytes, as well as mature erythrocytes, which occurred due to severe hypoferremia resulting from anemia of inflammation; however, plasma iron levels were attenuated probably through the inhibition of interleukin-6. Our data suggests that long-term treatment with p,p′-DDT induces microcytic anemia, possibly because of the impairment of iron utility in erythrocytes.
収録刊行物
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 38 (5), 775-782, 2013
一般社団法人 日本毒性学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390282679882874112
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- NII論文ID
- 10031191736
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- NII書誌ID
- AN00002808
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- COI
- 1:CAS:528:DC%2BC3sXhslyitbrJ
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- ISSN
- 18803989
- 03881350
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- NDL書誌ID
- 024934328
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- PubMed
- 24067725
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可