Sodium Carbonate is a Useful New Preservative for Collecting 24-hr Urine Samples to Measure Urinary C-peptide

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  • 尿中Ｃ－ペプチド測定用の蓄尿時添加剤としての炭酸ナトリウム製剤の検討
  • ニョウチュウ C-ペプチド ソクテイヨウ ノ チクニョウジ テンカザイ ト シテ ノ タンサン ナトリウム セイザイ ノ ケントウ

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The amount of urinary C-peptide (U-CPR) is a good parameter for estimating the insulin secretory ability of diabetic patients. However, a preservative must be added to urine samples to prevent reductions in the CPR level. Sodium azide (NaN3) is a routinely used preservative, but its use and handling are strictly controlled. A new preservative, composed mainly of Na2CO3, has been developed as a safer preservative. We examined the effects of this new preservative by comparing the 24-hr U-CPR levels obtained at 4°C and 28°C with or without NaN3 or Na2CO3. The C-peptide level was measured using two commercially available assay kits. The levels of U-CPR in urine samples kept at 28°C and containing Na2CO3 were well correlated with the levels of U-CPR in samples kept at 4°C and were higher than those in any other sample. Among the other urine components commonly measured by laboratories, urea nitrogen, creatinine and chloride were measured without any interference. This newly-eveloped preservative was therefore found to be a useful alternative to NaN3 for the accurate measurement of U-CPR levels.

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