Insulin Therapy with Glargine for Type 1 Diabetes in Japanese Adults
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- Yamamoto-Honda Ritsuko
- Department of Endocrinology and Metabolism, Institute for Adult Diseases, Asahi Life Foundation
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- Yoshida Yoko
- Department of Endocrinology and Metabolism, Institute for Adult Diseases, Asahi Life Foundation
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- Hara Yoko
- Department of Endocrinology and Metabolism, Institute for Adult Diseases, Asahi Life Foundation
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- Kawai Atsuo
- Department of Endocrinology and Metabolism, Institute for Adult Diseases, Asahi Life Foundation
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- Kitazato Hiroji
- Department of Endocrinology and Metabolism, Institute for Adult Diseases, Asahi Life Foundation
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- Sugasawa Gen
- Department of Endocrinology and Metabolism, Institute for Adult Diseases, Asahi Life Foundation
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- Noda Mitsuhiko
- Department of Endocrinology and Metabolism, Institute for Adult Diseases, Asahi Life Foundation
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- Kikuchi Masatoshi
- Department of Endocrinology and Metabolism, Institute for Adult Diseases, Asahi Life Foundation
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- Akanuma Yasuo
- Department of Endocrinology and Metabolism, Institute for Adult Diseases, Asahi Life Foundation
Bibliographic Information
- Other Title
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- 成人1型糖尿病におけるインスリングラルギンの12カ月間の使用経験
- セイジン 1ガタ トウニョウビョウ ニ オケル インスリングラルギン ノ 12カゲツカン ノ シヨウ ケイケン
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Abstract
We examined the efficacy of conversion from NPH insulin to glargine in Japanese type 1 diabetic adults using basal/bolus therapy. Retrospective chart analysis was done for 41 patients 12 months after switching to insulin glargine therapy. Insulin glargine was well tolerated with less frequent unrecognized hypoglycemia. After 6 months, the average HbA1c in the entire cohort dropped from 7.87±1.20% to 7.29±1.09% (p<0.01) but returned to initial levels after 12 months (7.87±1.03%, p>0.05). After the 12 months, the average insulin requirement per day of the cohort decreased from 37.4±13.9 units to 35.7±12.9 units (p<0.01). Of 25 patients injecting NPH insulin two or three times a day, 18 patients switched to single daily injections of insulin glargine. The average ratio of daily insulin glargine use to that of total insulin after 12 months was 0.35±0.09, similar to other reports from Japan, but smaller than that reported from other countries. Small body mass index (mean±S.D. 21.9±2.20 kg/m2) and a diet rich in carbohydrates among Japanese may require less basal insulin and more bolus insulin to control glycemia in Japanese patients with type 1 diabetes in adults.
Journal
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- Journal of the Japan Diabetes Society
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Journal of the Japan Diabetes Society 50 (1), 17-23, 2007
THE JAPAN DIABETES SOCIETY
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Details 詳細情報について
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- CRID
- 1390282679882932608
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- NII Article ID
- 10018570336
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- NII Book ID
- AN00166576
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- ISSN
- 1881588X
- 0021437X
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- NDL BIB ID
- 8687104
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed