糖尿病の早期じん障害の研究　　運動負荷試験による尿Ａｌｂｕｍｉｎ及び尿中ｌｙｓｏｓｏｍｅ酵素の変化

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タイトル別名
  • Changes in Urine Albumin and Urine Lysosome Induced by Exercise Test in Patients with Diabetes Mellitus
  • トウニョウビョウ ノ ソウキ ジン ショウガイ ノ ケンキュウ ウンドウ フカ
  • 運動負荷試験による尿Albumin及び尿中lysosome酵素の変化

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In order to study renal changes at the early stage in patients with diabetes mellitus, changes in urine albumin, urinary excretion and blood levels of N-acetyl-β-D-glucosaminidase (NAG), and urinary excretion of β-D-galactosidase (GAL) were determined before, during, and after exercise test by means of an ergometer in 16 patients with diabetes (15 NIDDM diabetics, one IDDM diabetic) and 10 normal subjects (controls). The following results were obtained.<BR>1) In normal subjects, the urine albumin did not increase. Taking the level in normal subjects, X+2SD, as the normal range, it increased to a level in excess of the normal range in 6 patients with diabetes during and after the exercise test, and it increased slightly in 3 patients before or only after the test.<BR>2) The serum NAG increased more significantly in the patients who showed an increase in urine albumin than in the patients who showed no increase in urine albumin.<BR>3) There were no differences in urine NAG or GAL before, during, or after the exercise test. The urine NAG in patients with diabetes increased more significantly than that in the normal subjects before and during the exercise test.<BR>4) The urinary excretion of albumin was significantly correlated to the urinary excretion of NAG, and to the urinary excretion of GAL, in patients with diabetes during and after the exercise test. Based on the above results, the urine NAG and urine GAL were considered to be involved in the occurrence of renal changes at the early stage of diabetes and to represent good indices for the early detection of diabetes mellitus.

収録刊行物

  • 糖尿病

    糖尿病 25 (7), 777-783, 1982

    一般社団法人 日本糖尿病学会

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