糖尿病患者における赤血球インスリン結合に関する研究　Ｉ　　正常健常人における加齢の影響，耐糖能低下による変化，Ｔｙｐｅ　ＩＩ糖尿病患者におけるインスリン結合とインスリン抵抗性の相関

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書誌事項

タイトル別名
  • Studies on Insulin Binding to Erythrocytes (I)
  • トウニョウビョウ カンジャ ニ オケル セッケッキュウ インスリン ケツゴウ
  • 正常健常人における加齢の影響, 耐糖能低下による変化, Type II糖尿病患者におけるインスリン結合とインスリン抵抗性の相関

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抄録

In order to study the insulin receptor kinetics under normal and pathophysiological conditions in humans with a small amount of blood, we assayed the insulin binding to erythrocytes from normal subjects (cord blood, 8 subjects; 6 mo to 6 yr old, 13; 7 to 19 yr old, 13; 20 to 59 yr old, 30; over 60 yr old, 12), 8 borderline diabetics by 50 g OGTT and 34 untreated Type II NIDDM patients. We also tested the insulin sensitivity of diabetic subjects by the method using somatostatin.<BR>Cord blood showed the highest insulin binding with an increased number of binding sites on the erythrocytes (R0). The other 4 groups of normals demonstrated increasing binding with age due to increased binding affinity (Ke) without changes in R0.<BR>The insulin binding was inversely correlated with the degree of impaired glucose tolerance. A broad distribution of insulin binding was observed in the diabetic patients due to the differences in Ke. Type H (diabetics with tracer bindings above the mean of those of diabetics: 4.86%, n=18). demonstrated higher FPG, lower insulin secretion and more insulin resistant as judged by the insulin sensitivity test than Type L (below 4.86%, n=16). The increased Ke observed in Type H failed to compensate the insulin resistance, suggesting that the changes in Ke did not contribute to amelioration of the insulin resistance.

収録刊行物

  • 糖尿病

    糖尿病 25 (7), 803-811, 1982

    一般社団法人 日本糖尿病学会

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