Pancreatic Polypeptide and Insulin Contents in Diabetic and Nondiabetic Human Pancreas and Their Relation to the Clinical Pictures During Diabetic Life

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  • Tasaka Y.
    Diabetes Center, Tokyo Women's Medical College
  • Iwatani M.
    Diabetes Center, Tokyo Women's Medical College
  • Inoue M.
    Diabetes Center, Tokyo Women's Medical College
  • Marumo K.
    Diabetes Center, Tokyo Women's Medical College
  • Hirata Y.
    Diabetes Center, Tokyo Women's Medical College

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  • 糖尿病ならびに非糖尿病患者のすい組織Ｐａｎｃｒｅａｔｉｃ　ＰｏｌｙｐｅｐｔｉｄｅならびにＩｎｓｕｌｉｎ量と生前の臨床像との関係について
  • トウニョウビョウ ナラビニ ヒ トウニョウビョウ カンジャ ノ スイ ソシキ

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The amounts of insulin and pancreatic polypeptide (PP) in the human pancreas within 6 hours after death were determined in 26 diabetic and 19 nondiabetic autopsy cases. The relations to the stability of fasting serum glucose based on the standard deviation of 15 determinations, and to renal or hepatic insufficiency were also investigated. The following results were obtained.<BR>1) Gel filtration of acid ethanol extracts with a Sephadex G50 column revealed single insulin, PP and C-peptide peaks.<BR>2) The PP contents at the tail of the pancreas in the diabetic and nondiabetic subjects were 9.55±2.41 μg/g and 7.71±1.52 μg/g wet weight of pancreas, respectively. Those at the head of the pancreas were 16.86±5.51 μg/g and 15.82±5.38 μg/g, respectively. No significant differences were found between the diabetic and nondiabetic values or between those at the tail and at the head of the pancreas. The PP contents at the head of the pancreas including both the diabetic and nondiabetic subjects were significantly higher than those at the tail (p<0.02).<BR>3) The insulin content at the tail of the diabetic pancreas was lower than that in the nondiabeticpancreas (p<0.01). The values were 1.26±0.19 U/g and 2.55±0.35 U/g, respectively. The content at the head of the diabetic pancreas was not significantly different from that in the nondiabetic pancreas. The values were 1.14±0.27 U/g and 1.60±0.23 U/g, respectively.<BR>4) In cases containing less than 0.5 U/g of insulin at the tail of the diabetic pancreas, the stability of the fasting serum glucose was very poor, indicating an unstable type of diabetes. However, the PP contents of the pancreas revealed no relation with the stability of the fasting serum glucose.<BR>5) Renal insufficiency in the diabetics exerted no aggravating effect on the stability of the fasting serum glucose, and revealed no relation with the pancreatic contents of insulin or PP. In cases with hepatic insufficiency among the diabetics, the stability of the fasting serum glucose was somewhat poor, suggesting some contribution by liver insufficiency in the control of the blood sugar level.

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