力士における糖尿病発症の分析，とくに発症前のインスリン分泌との関係

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  • Follow-up of Sumo-wrestlers for 5-14 Years. Relationship of Development of Diabetes Mellitus with Blood Glucose and Insulin Levels of the Initial Glucose Tolerance Test

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Among 196 active and retired sumo-wrestlers examined by means of a 100 g glucose tolerance test (GTT) in 1968-1969, follow-up data on fasting blood glucose (FBG) were obtained in 40 cases. The types of GTT were divided into 4 categories according to the new criteria of the Japan Diabetic Society as follows: normal, FBG <140 and 2-hr blood glucose (BG)<130 mg/d1: borderline, FBG <140 and 2 hr BG 130-159 mg/dl; IGT, FBG <140 and 2-hr BG 160-239 mg/dl; and diabetic, FBG >140 and/or 2-hr BG >240 mg/dl. Seven were already diabetic at the initial survey. Sixteen subjects in the normal type (6/19), borderline type (4/8), and IGT (6/6) groups became newly diabetic. The ratio of increment of serum insulin (pU/m/) to that of glucose (mg/d/) 30 minutes after a 100-g glucose load (Δ IRI/Δ BG) was 0.86 ± 0.67 (Mean ± SD) in subjects who later developed diabetes, while it was 1.39± O.97 in those who did not (p<O.1). Eleven out of 17 subjects (65%) in the normal-IGT groups with an initial Δ IRI/Δ BG lower than I.0 became diabetic, and 5 out of 16 subjects (31%) of those with an initial Δ IRI/ΔBG higher than 1.0 (p<O.1) became diabetic. There was no difference between groups of subjects who became diabetic and those who did not become diabetic in the initial and post-follow-up ages, the status of activity (active or retired), and the initial and subsequent weight index.<BR>In conclusion, diabetes occurred more frequently in those who had more impaired initial glucose tolerance and lower Δ IRI/Δ BG. However, a considerable number of subjects with Δ IRI/Δ BG higher than 1.0 at the initial GTT became diabetic. Acquired diabetogenic factors such as obesity, if they are strong, may induce diabetes even in subjects with normal insulin response.

収録刊行物

  • 糖尿病

    糖尿病 27 (1), 59-64, 1984

    一般社団法人 日本糖尿病学会

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