The Effectiveness of Shakuyaku-kanzo-to on Myotonia in a Case of Myotonic Dystrophy.

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  • 筋緊張性ジストロフィー症のミオトニーにしゃく楽甘草湯が有効であった一例
  • キン キンチョウセイ ジストロフィーショウ ノ ミオトニー ニ シャクヤクカン

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Abstract

The effectiveness of Shakuyaku-kanzo-to on myotonia in a 50-year-old female with myotonic dystrophy is reported. Neurological examination showed myogenic distal dominant muscle weakness and myotonia. Treatment with Shakuyaku-kanzo-to improved myotonic time from 12.8 to 6.8 seconds. This effect was equal to phenytoin and mexiletine. The results indicated that Shakuyaku-kanzo-to affected the ion channels of the skeletal muscle membrane. The apaminsensitive K channel was speculated to be the affected site of the ion channel. Glycyrrhizin might play an important role in this mechanism.<br>Five week treatment with Shakuyaku-kanzo-to showed no adverse effects on the myopathy.

Journal

  • Kampo Medicine

    Kampo Medicine 46 (5), 773-778, 1996

    The Japan Society for Oriental Medicine

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